One of the most frustrating problems in infertility today is IVF failure - also called implantation failure. This refers to infertile patients who have undergone many IVF cycles and produced beautiful embryos - but the embryos have consistently failed to implant for unexplained reasons. 
Many patients who fail an IVF cycle often give up. Not only are they disappointed, they are also upset about the fact that their doctor does not usually give them a clear explanation for why the IVF cycle failed - or what they can do differently the next time, to improve their chances of success. While some stop for financial reasons, others come to the conclusion that they are destined to never have a baby; and admit defeat prematurely.
Hospitals of India partner Clinics/Hospitals pregnancy rates in patients who have failed IVF cycles elsewhere is very high, because we can transfer more embryos in difficult patients (unlike fertility clinics in UK and Australia, where the number of embryos which can be transferred is limited by law). While transferring more embryos does increase the risk of high-order multiple pregnancies, this risk is negligible in difficult patients (for example, the older women or women with previous failed IVF cycles). In our fertility clinic, we customise the number of embryos we transfer for each patient we treat, rather than just blindly follow a guideline (which has been laid down for the general population, without considering each individual's specific problem).
The other common reason for a failed IVF cycle is a poor ovarian response, which means patients get few eggs and few embryos. For these patients, we offer the option of aggressive super ovulation, with high doses of HMG, in order to help them grow more eggs, so we have more embryos to transfer.
For patients with a poor ovarian response, we also offer the option of GIFT - gamete intra fallopian transfer, in which we transfer the eggs and sperm directly into the fallopian tubes by performing a laparoscopy. This has a better pregnancy rate than IVF, because we put the eggs and sperm back where they belong - in the fallopian tubes, rather than in our incubator. 
Sometimes the reason for IVF failure is because the embryo transfer was technically difficult, because of cervical stenosis. This means that the transfer is often traumatic, and is associated with bleeding. For these patients, if their fallopian tubes are open, we prefer doing a fallopian tube transfer ( ZIFT zygote intra fallopian transfer) so that we can bypass the cervix and place the embryos directly in the fallopian tubes. This ensures a very high pregnancy rate.
Another group of patients who often do poorly in other IVF clinics are those who have PCOD. Because many doctors are so worried about the danger of OHSS (ovarian hyper stimulation) in these patients, they often end up super ovulating these patients badly, and retrieve few poor quality eggs, compromising the pregnancy rate. In our fertility clinic, we prevent OHSS by carefully aspirating each and every follicle at the time of egg retrieval , and flushing it repeatedly with a double-lumen needle, until it collapses completely. By removing the follicular cells which are responsible for producing VEGF and causing OHSS, we have been able to prevent OHSS in PCOD patients very successfully in our fertility clinics/hospitals by using this novel technique.
Successful embryo implantation depends upon the health of the embryo, and one of the reasons embryos may fail to implant is that they may be chromosomally abnormal (even though they look normal). Research has shown that the incidence of chromosomal abnormalities even in good looking embryos is as high as 50% !
We can also offer the following advanced technique to help patients who have failed multiple cycles of IVF.
After In Vitro fertilization, which is performed in the normal fashion, we perform an embryo biopsy on Day 3, using a laser, and study the genetic composition of each embryo. This allows to select only the chromosomally normal embryos. The normal embryos are then transferred into the uterus on Day 5, when they are blastocysts.
This combined technique offers many advantages, especially for older women, who are more likely to produce abnormal embryos.
1. It allows us to select the chromosomally normal embryos. Not only does this increase the chances of embryo implantation, it also means the risk of a genetically abnormal baby is reduced.
2. We drill the zona with a laser. This allows us to facilitate embryo hatching , thus increasing the chances of embryo implantation.
3. Since we are transferring blastcysts on Day 5, the synchronisation between embryo and the endomterium is increased, thus enhancing implantation.
4. Since we can transfer fewer embryos ( each embryo now has a higher chance of becoming a baby ), the risk of multiple pregnancies is also reduced. 
Since this technique is very labour-intensive and technologically demanding, the cost is more than that of a regular IVF cycle. However, for patients who have failed 2 IVF cycles, and are not happy about the idea of repeating another similar IVF cycle again; and for older patients, this advanced option can be very cost-effective.
